CLINICAL TRIALS

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CURRENT RETT SYNDROME CLINICAL TRIALS

To learn more about clinical trials please visit the clinicaltrials.gov website

CLINICAL TRIAL SPOTLIGHT

 

OSTEOPOROSIS IN RETT SYNDROME (OSRETT)

 

LOCATION:France
COLLABORATORS:Assistance Publique – Hôpitaux de Paris

 

SUMMARY

Based on our clinical observations, many girls with RETT syndrome, a severe neuro-developmental encephalopathy, suffer from osteoporosis which can appear at a very early age (before age 10) and can lead to fractures, pain and a limitation in mobility. Few epidemiological studies have estimated the frequency of osteoporosis in girls with RETT syndrome and showed that they are more exposed then children with other neuro-developmental diseases with a same degree of neurological handicap. However, the mechanisms that lead to early osteoporosis in RETT syndrome
remain unknown. Mutations in the MECP2 gene are found in 95% of RETT patients and preliminary experimental studies have shown that this can lead to abnormal expression of the gene that codes for osteoprotegerin, a protein implicated in bone remodelling by interacting with RANK-ligand.

In order to identify risk factors of osteoporosis in RETT syndrome and to understand the pathophysiological mechanisms the study protocol includes:

  • Clinical evaluation of bone health (history of bone fractures, pain, nutritional status, pubertal stage, daily caloric/calcium intake, anti-epileptic drugs, walking ability, vitamin D satus)
  • evaluation of the mineral density at the lumber spine using DEXA
  • measuring concentrations of osteoprotegerin and RANK-ligand

 

CLINICALTRIALS.GOV IDENTIFIER:NCT02110797

CONTACT:agnès linglart, M | email: agnes.linglart@inserm.fr
CONTACT:laurence Lecomte, PhD | Tel: 1 71 19 64 94 ext +33 | email: laurence.lecomte@nck.aphp.fr

 

BELOW IS A LIST OF OTHER CURRENT TRIALS AND STUDIES:

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